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Exploring the Complexity of the HIV-1 Fitness Landscape

Although fitness landscapes are central to evolutionary theory, so far no biologically realistic examples for large-scale fitness landscapes have been described. Most currently available biological examples are restricted to very few loci or alleles and therefore do not capture the high dimensionali...

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Detalles Bibliográficos
Autores principales: Kouyos, Roger D., Leventhal, Gabriel E., Hinkley, Trevor, Haddad, Mojgan, Whitcomb, Jeannette M., Petropoulos, Christos J., Bonhoeffer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297571/
https://www.ncbi.nlm.nih.gov/pubmed/22412384
http://dx.doi.org/10.1371/journal.pgen.1002551