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Outgrowth of Single Oncogene-expressing Cells from Suppressive Epithelial Environments

Tumorigenesis is a clonal evolution process initiated from single cells within otherwise histologically normal tissue(1). How single, sporadic mutant cells that have sustained oncogenic alterations evolve within tightly regulated tissue environment remains elusive. Here, we investigated the effects...

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Detalles Bibliográficos
Autores principales: Leung, Cheuk T., Brugge, Joan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297969/
https://www.ncbi.nlm.nih.gov/pubmed/22318515
http://dx.doi.org/10.1038/nature10826