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Dose-Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity
INTRODUCTION: Sulfobutylether-β-cyclodextrin (SBE-CD) is a pharmaceutical excipient known to bind verapamil. Following intravenous administration, clearance of SBE-CD approximates glomerular filtration rate. We hypothesized that infusion of SBE-CD would increase time to asystole in a rat model of ve...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Department of Emergency Medicine, University of California, Irvine
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298207/ https://www.ncbi.nlm.nih.gov/pubmed/22461924 http://dx.doi.org/10.5811/westjem.2011.3.6696 |