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Dose-Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity

INTRODUCTION: Sulfobutylether-β-cyclodextrin (SBE-CD) is a pharmaceutical excipient known to bind verapamil. Following intravenous administration, clearance of SBE-CD approximates glomerular filtration rate. We hypothesized that infusion of SBE-CD would increase time to asystole in a rat model of ve...

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Detalles Bibliográficos
Autores principales:	Mottram, Allan R, Bryant, Sean M, Aks, Steven E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Department of Emergency Medicine, University of California, Irvine 2012
Materias:	Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298207/ https://www.ncbi.nlm.nih.gov/pubmed/22461924 http://dx.doi.org/10.5811/westjem.2011.3.6696

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