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Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes
BACKGROUND: Japanese encephalitis virus (JEV) infection is a major cause of acute encephalopathy in children, which destroys central nervous system (CNS) cells, including astrocytes and neurons. Matrix metalloproteinase (MMP)-9 has been shown to degrade components of the basal lamina, leading to dis...
Autores principales: | Yang, Chuen-Mao, Lin, Chih-Chung, Lee, I-Ta, Lin, Yi-Hsin, Yang, Caleb M, Chen, Wei-June, Jou, Mei-Jie, Hsiao, Li-Der |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298505/ https://www.ncbi.nlm.nih.gov/pubmed/22251375 http://dx.doi.org/10.1186/1742-2094-9-12 |
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