CD6 attenuates early and late signaling events, setting thresholds for T-cell activation

The T lineage glycoprotein CD6 is generally considered to be a costimulator of T-cell activation. Here, we demonstrate that CD6 significantly reduces early and late T-cell responses upon superantigen stimulation or TCR triggering by Abs. Measuring calcium mobilization in single cells responding to s...

Descripción completa

Detalles Bibliográficos
Autores principales: Oliveira, Marta I, Gonçalves, Carine M, Pinto, Mafalda, Fabre, Stéphanie, Santos, Ana Mafalda, Lee, Simon F, Castro, Mónica A A, Nunes, Raquel J, Barbosa, Rita R, Parnes, Jane R, Yu, Chao, Davis, Simon J, Moreira, Alexandra, Bismuth, Georges, Carmo, Alexandre M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Leukocyte Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298641/
https://www.ncbi.nlm.nih.gov/pubmed/21956609
http://dx.doi.org/10.1002/eji.201040528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298641/
https://www.ncbi.nlm.nih.gov/pubmed/21956609
http://dx.doi.org/10.1002/eji.201040528

Ejemplares similares