Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity

Toll-like receptors (TLRs) shape innate and adaptive immunity to microorganisms. The enzyme IRAK1 transduces signals from TLRs, but its activation and regulation mechanisms remain unknown. We show that TLR7 and TLR9 activated the isomerase Pin1, which then bound to IRAK1, resulting in IRAK1 activati...

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Detalles Bibliográficos
Autores principales: Tun-Kyi, Adrian, Finn, Greg, Greenwood, Alex, Nowak, Michael, Lee, Tae Ho, Asara, John M., Tsokos, George C., Fitzgerald, Kate, Israel, Elliot, Li, Xiaoxia, Exley, Mark, Nicholson, Linda K., Lu, Kun Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298750/
https://www.ncbi.nlm.nih.gov/pubmed/21743479
http://dx.doi.org/10.1038/ni.2069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298750/
https://www.ncbi.nlm.nih.gov/pubmed/21743479
http://dx.doi.org/10.1038/ni.2069

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