Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes

BACKGROUND: Cholesterol pathways play an important role at multiple stages during the HIV-1 infection cycle. Here, we investigated the role of cholesterol trafficking in HIV-1 replication utilizing Niemann-Pick Type C disease (NPCD) cells as a model system. RESULTS: We used a unique NPC2-deficient c...

Descripción completa

Detalles Bibliográficos
Autores principales: Coleman, Ebony M, Walker, Tiffany N, Hildreth, James EK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299633/
https://www.ncbi.nlm.nih.gov/pubmed/22273177
http://dx.doi.org/10.1186/1743-422X-9-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299633/
https://www.ncbi.nlm.nih.gov/pubmed/22273177
http://dx.doi.org/10.1186/1743-422X-9-31

Ejemplares similares