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Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes

BACKGROUND: Cholesterol pathways play an important role at multiple stages during the HIV-1 infection cycle. Here, we investigated the role of cholesterol trafficking in HIV-1 replication utilizing Niemann-Pick Type C disease (NPCD) cells as a model system. RESULTS: We used a unique NPC2-deficient c...

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Detalles Bibliográficos
Autores principales:	Coleman, Ebony M, Walker, Tiffany N, Hildreth, James EK
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299633/ https://www.ncbi.nlm.nih.gov/pubmed/22273177 http://dx.doi.org/10.1186/1743-422X-9-31

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