Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in cell proliferation and survival in human tumorigenesis, including gastric cancer. PIK3CA mutations and amplification are two major causes of overactivation of this pathway in human cancers. However, until this w...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Jing, Yao, Demao, Liu, Wei, Wang, Na, Lv, Hongjun, Zhang, Guanjun, Ji, Meiju, Xu, Li, He, Nongyue, Shi, Bingyin, Hou, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299648/
https://www.ncbi.nlm.nih.gov/pubmed/22292935
http://dx.doi.org/10.1186/1471-2407-12-50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299648/
https://www.ncbi.nlm.nih.gov/pubmed/22292935
http://dx.doi.org/10.1186/1471-2407-12-50

Ejemplares similares