Calpain Cleavage of Brain Glutamic Acid Decarboxylase 65 Is Pathological and Impairs GABA Neurotransmission

Previously, we have shown that the GABA synthesizing enzyme, L-glutamic acid decarboxylase 65 (GAD65) is cleaved to form its truncated form (tGAD65) which is 2–3 times more active than the full length form (fGAD65). The enzyme responsible for cleavage was later identified as calpain. Calpain is know...

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Detalles Bibliográficos
Autores principales: Buddhala, Chandana, Suarez, Marjorie, Modi, Jigar, Prentice, Howard, Ma, Zhiyuan, Tao, Rui, Wu, Jang Yen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299728/
https://www.ncbi.nlm.nih.gov/pubmed/22427928
http://dx.doi.org/10.1371/journal.pone.0033002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299728/
https://www.ncbi.nlm.nih.gov/pubmed/22427928
http://dx.doi.org/10.1371/journal.pone.0033002

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