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Reducing agents affect inhibitory activities of compounds: Results from multiple drug targets

High-throughput screening (HTS) of large compound libraries has become a commonly used method for the identification of drug leads, and nonphysiological reducing agents have been widely used for HTS. However, a comparison of the difference in the HTS results based on the choice of reducing agent use...

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Detalles Bibliográficos
Autores principales: Lee, Hyun, Torres, Jaime, Truong, Lena, Chaudhuri, Rima, Mittal, Anuradha, Johnson, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299889/
https://www.ncbi.nlm.nih.gov/pubmed/22310499
http://dx.doi.org/10.1016/j.ab.2012.01.006