Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group

The conjugation of siRNA to molecules, which can be internalized into the cell via natural transport mechanisms, can result in the enhancement of siRNA cellular uptake. Herein, the carrier-free cellular uptake of nuclease-resistant anti-MDR1 siRNA equipped with lipophilic residues (cholesterol, lith...

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Detalles Bibliográficos
Autores principales: Petrova, Natalya S., Chernikov, Ivan V., Meschaninova, Mariya I., Dovydenko, IIya S., Venyaminova, Aliya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299988/
https://www.ncbi.nlm.nih.gov/pubmed/22080508
http://dx.doi.org/10.1093/nar/gkr1002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299988/
https://www.ncbi.nlm.nih.gov/pubmed/22080508
http://dx.doi.org/10.1093/nar/gkr1002

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