Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling

The human prolyl-4-hydroxylase domain (PHD) proteins 1–3 are known as cellular oxygen sensors, acting via the degradation of hypoxia-inducible factor (HIF) α-subunits. PHD2 and PHD3 genes are inducible by HIFs themselves, suggesting a negative feedback loop that involves PHD abundance. To identify n...

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Detalles Bibliográficos
Autores principales: Wollenick, Kristin, Hu, Jun, Kristiansen, Glen, Schraml, Peter, Rehrauer, Hubert, Berchner-Pfannschmidt, Utta, Fandrey, Joachim, Wenger, Roland H., Stiehl, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3300025/
https://www.ncbi.nlm.nih.gov/pubmed/22075993
http://dx.doi.org/10.1093/nar/gkr978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3300025/
https://www.ncbi.nlm.nih.gov/pubmed/22075993
http://dx.doi.org/10.1093/nar/gkr978

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