Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.

Detalles Bibliográficos
Autores principales: Jones, Raymond C F, Choudhury, Abdul K, Iley, James N, Light, Mark E, Loizou, Georgia, Pillainayagam, Terence A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302094/
https://www.ncbi.nlm.nih.gov/pubmed/22423299
http://dx.doi.org/10.3762/bjoc.8.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302094/
https://www.ncbi.nlm.nih.gov/pubmed/22423299
http://dx.doi.org/10.3762/bjoc.8.33

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