Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.

Detalles Bibliográficos
Autores principales: Jones, Raymond C F, Choudhury, Abdul K, Iley, James N, Light, Mark E, Loizou, Georgia, Pillainayagam, Terence A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302094/
https://www.ncbi.nlm.nih.gov/pubmed/22423299
http://dx.doi.org/10.3762/bjoc.8.33
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author Jones, Raymond C F
Choudhury, Abdul K
Iley, James N
Light, Mark E
Loizou, Georgia
Pillainayagam, Terence A
author_facet Jones, Raymond C F
Choudhury, Abdul K
Iley, James N
Light, Mark E
Loizou, Georgia
Pillainayagam, Terence A
author_sort Jones, Raymond C F
collection PubMed
description A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.
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spelling pubmed-33020942012-03-15 Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones Jones, Raymond C F Choudhury, Abdul K Iley, James N Light, Mark E Loizou, Georgia Pillainayagam, Terence A Beilstein J Org Chem Full Research Paper A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products. Beilstein-Institut 2012-02-27 /pmc/articles/PMC3302094/ /pubmed/22423299 http://dx.doi.org/10.3762/bjoc.8.33 Text en Copyright © 2012, Jones et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Jones, Raymond C F
Choudhury, Abdul K
Iley, James N
Light, Mark E
Loizou, Georgia
Pillainayagam, Terence A
Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
title Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
title_full Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
title_fullStr Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
title_full_unstemmed Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
title_short Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
title_sort aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302094/
https://www.ncbi.nlm.nih.gov/pubmed/22423299
http://dx.doi.org/10.3762/bjoc.8.33
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