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Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.

Detalles Bibliográficos
Autores principales:	Jones, Raymond C F, Choudhury, Abdul K, Iley, James N, Light, Mark E, Loizou, Georgia, Pillainayagam, Terence A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2012
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302094/ https://www.ncbi.nlm.nih.gov/pubmed/22423299 http://dx.doi.org/10.3762/bjoc.8.33

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