Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

Neurotrophin growth factors support neuronal survival and function. In this study, we show that the expression of the neurotrophin receptor TrkB is induced on astrocytes in white matter lesions in multiple sclerosis (MS) patients and mice with experimental autoimmune encephalomyelitis (EAE). Surpris...

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Detalles Bibliográficos
Autores principales: Colombo, Emanuela, Cordiglieri, Chiara, Melli, Giorgia, Newcombe, Jia, Krumbholz, Markus, Parada, Luis F., Medico, Enzo, Hohlfeld, Reinhard, Meinl, Edgar, Farina, Cinthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302220/
https://www.ncbi.nlm.nih.gov/pubmed/22393127
http://dx.doi.org/10.1084/jem.20110698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302220/
https://www.ncbi.nlm.nih.gov/pubmed/22393127
http://dx.doi.org/10.1084/jem.20110698

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