Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical intervention. Notch pathway antagonism has been shown to prevent pancreatic preneoplasia progression in mouse models, but potential benefits in the setting of an established PDA tumor have not been establ...

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Detalles Bibliográficos
Autores principales: Cook, Natalie, Frese, Kristopher K., Bapiro, Tashinga E., Jacobetz, Michael A., Gopinathan, Aarthi, Miller, Jodi L., Rao, Sudhir S., Demuth, Tim, Howat, William J., Jodrell, Duncan I., Tuveson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302221/
https://www.ncbi.nlm.nih.gov/pubmed/22351932
http://dx.doi.org/10.1084/jem.20111923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302221/
https://www.ncbi.nlm.nih.gov/pubmed/22351932
http://dx.doi.org/10.1084/jem.20111923

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