An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

Replicative stress (RS) is a type of endogenous DNA damage that cells suffer every time they duplicate their genomes, and which is further boosted by oncogenes. In mammals, the RS response (RSR) is coordinated by ATR and Chk1 kinases. We sought to develop a mammalian organism that is selectively pro...

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Detalles Bibliográficos
Autores principales: López-Contreras, Andres J., Gutierrez-Martinez, Paula, Specks, Julia, Rodrigo-Perez, Sara, Fernandez-Capetillo, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302228/
https://www.ncbi.nlm.nih.gov/pubmed/22370720
http://dx.doi.org/10.1084/jem.20112147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302228/
https://www.ncbi.nlm.nih.gov/pubmed/22370720
http://dx.doi.org/10.1084/jem.20112147

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