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Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection
The molecular mechanisms that drive mucosal T helper type 2 (T(H)2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell–derived repair molecule, is needed for the control of lung injury caused by t...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302229/ https://www.ncbi.nlm.nih.gov/pubmed/22329990 http://dx.doi.org/10.1084/jem.20110079 |
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author | Wills-Karp, Marsha Rani, Reena Dienger, Krista Lewkowich, Ian Fox, James G. Perkins, Charles Lewis, Lauren Finkelman, Fred D. Smith, Dirk E. Bryce, Paul J. Kurt-Jones, Evelyn A. Wang, Timothy C. Sivaprasad, Umasundari Hershey, Gurjit K. Herbert, De’Broski R. |
author_facet | Wills-Karp, Marsha Rani, Reena Dienger, Krista Lewkowich, Ian Fox, James G. Perkins, Charles Lewis, Lauren Finkelman, Fred D. Smith, Dirk E. Bryce, Paul J. Kurt-Jones, Evelyn A. Wang, Timothy C. Sivaprasad, Umasundari Hershey, Gurjit K. Herbert, De’Broski R. |
author_sort | Wills-Karp, Marsha |
collection | PubMed |
description | The molecular mechanisms that drive mucosal T helper type 2 (T(H)2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell–derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. TFF2 is also necessary for the rapid production of IL-33, a T(H)2-promoting cytokine, by lung epithelia, alveolar macrophages, and inflammatory dendritic cells in infected mice. TFF2 also increases the severity of allergic lung disease caused by house dust mite antigens or IL-13. Moreover, TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children. These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal T(H)2 responses. |
format | Online Article Text |
id | pubmed-3302229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33022292012-09-12 Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection Wills-Karp, Marsha Rani, Reena Dienger, Krista Lewkowich, Ian Fox, James G. Perkins, Charles Lewis, Lauren Finkelman, Fred D. Smith, Dirk E. Bryce, Paul J. Kurt-Jones, Evelyn A. Wang, Timothy C. Sivaprasad, Umasundari Hershey, Gurjit K. Herbert, De’Broski R. J Exp Med Article The molecular mechanisms that drive mucosal T helper type 2 (T(H)2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell–derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. TFF2 is also necessary for the rapid production of IL-33, a T(H)2-promoting cytokine, by lung epithelia, alveolar macrophages, and inflammatory dendritic cells in infected mice. TFF2 also increases the severity of allergic lung disease caused by house dust mite antigens or IL-13. Moreover, TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children. These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal T(H)2 responses. The Rockefeller University Press 2012-03-12 /pmc/articles/PMC3302229/ /pubmed/22329990 http://dx.doi.org/10.1084/jem.20110079 Text en © 2012 Wills-Karp et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Article Wills-Karp, Marsha Rani, Reena Dienger, Krista Lewkowich, Ian Fox, James G. Perkins, Charles Lewis, Lauren Finkelman, Fred D. Smith, Dirk E. Bryce, Paul J. Kurt-Jones, Evelyn A. Wang, Timothy C. Sivaprasad, Umasundari Hershey, Gurjit K. Herbert, De’Broski R. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection |
title | Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection |
title_full | Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection |
title_fullStr | Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection |
title_full_unstemmed | Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection |
title_short | Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection |
title_sort | trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302229/ https://www.ncbi.nlm.nih.gov/pubmed/22329990 http://dx.doi.org/10.1084/jem.20110079 |
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