Thymic negative selection is functional in NOD mice

Based on analyses of multiple TCR transgenic (tg) models, the emergence of pathogenic T cells in diabetes-prone NOD mice has been ascribed to a failure to censure autoreactive clones in the thymus. In contrast, using isolated and preselected thymocytes, we show that nonobese diabetic (NOD) genetic v...

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Detalles Bibliográficos
Autores principales: Mingueneau, Michael, Jiang, Wenyu, Feuerer, Markus, Mathis, Diane, Benoist, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302233/
https://www.ncbi.nlm.nih.gov/pubmed/22329992
http://dx.doi.org/10.1084/jem.20112593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302233/
https://www.ncbi.nlm.nih.gov/pubmed/22329992
http://dx.doi.org/10.1084/jem.20112593

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