Cargando…
Thymic negative selection is functional in NOD mice
Based on analyses of multiple TCR transgenic (tg) models, the emergence of pathogenic T cells in diabetes-prone NOD mice has been ascribed to a failure to censure autoreactive clones in the thymus. In contrast, using isolated and preselected thymocytes, we show that nonobese diabetic (NOD) genetic v...
Autores principales: | Mingueneau, Michael, Jiang, Wenyu, Feuerer, Markus, Mathis, Diane, Benoist, Christophe |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302233/ https://www.ncbi.nlm.nih.gov/pubmed/22329992 http://dx.doi.org/10.1084/jem.20112593 |
Ejemplares similares
-
Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints
por: Nishio, Junko, et al.
Publicado: (2010) -
Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging
por: Fu, Wenxian, et al.
Publicado: (2012) -
Aire controls gene expression in the thymic epithelium with ordered stochasticity
por: Meredith, Matthew, et al.
Publicado: (2015) -
CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance
por: Michelson, Daniel A., et al.
Publicado: (2022) -
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
por: Gray, Daniel, et al.
Publicado: (2007)