A Dominant Negative ERβ Splice Variant Determines the Effectiveness of Early or Late Estrogen Therapy after Ovariectomy in Rats

The molecular mechanisms for the discrepancy in outcome of initiating estrogen therapy (ET) around peri-menopause or several years after menopause in women are unknown. We hypothesize that the level of expression of a dominant negative estrogen receptor (ER) β variant, ERβ2, may be a key factor dete...

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Detalles Bibliográficos
Autores principales: Wang, Jun Ming, Hou, Xu, Adeosun, Samuel, Hill, Rosanne, Henry, Sherry, Paul, Ian, Irwin, Ronald W., Ou, Xiao-Ming, Bigler, Steven, Stockmeier, Craig, Brinton, Roberta Diaz, Gomez-Sanchez, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302771/
https://www.ncbi.nlm.nih.gov/pubmed/22428062
http://dx.doi.org/10.1371/journal.pone.0033493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302771/
https://www.ncbi.nlm.nih.gov/pubmed/22428062
http://dx.doi.org/10.1371/journal.pone.0033493

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