A Model for How Signal Duration Can Determine Distinct Outcomes of Gene Transcription Programs

The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood. It is known that IL-6 induces a transient STAT3 signal and that IL-10 induces a sustained STAT3...

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Detalles Bibliográficos
Autores principales: Fowler, Kevin D., Kuchroo, Vijay K., Chakraborty, Arup K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302786/
https://www.ncbi.nlm.nih.gov/pubmed/22427931
http://dx.doi.org/10.1371/journal.pone.0033018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302786/
https://www.ncbi.nlm.nih.gov/pubmed/22427931
http://dx.doi.org/10.1371/journal.pone.0033018

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