Muscleblind-Like 1 Knockout Mice Reveal Novel Splicing Defects in the Myotonic Dystrophy Brain

Myotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by a CTG trinucleotide repeat expansion (CTG(exp)) in the DMPK gene. In skeletal muscle, nuclear sequestration of the alternative splicing factor muscleblind-like 1 (MBNL1) explains the majority of the alternative splicing defects o...

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Detalles Bibliográficos
Autores principales: Suenaga, Koichi, Lee, Kuang-Yung, Nakamori, Masayuki, Tatsumi, Yoshiki, Takahashi, Masanori P., Fujimura, Harutoshi, Jinnai, Kenji, Yoshikawa, Hiroo, Du, Hongqing, Ares, Manuel, Swanson, Maurice S., Kimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302840/
https://www.ncbi.nlm.nih.gov/pubmed/22427994
http://dx.doi.org/10.1371/journal.pone.0033218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302840/
https://www.ncbi.nlm.nih.gov/pubmed/22427994
http://dx.doi.org/10.1371/journal.pone.0033218

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