Cargando…

Chronic Allergic Inflammation Causes Vascular Remodeling and Pulmonary Hypertension in Bmpr2 Hypomorph and Wild-Type Mice

Loss-of-function mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene have been identified in patients with heritable pulmonary arterial hypertension (PAH); however, disease penetrance is low, suggesting additional factors play a role. Inflammation is associated with PAH and vasc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mushaben, Elizabeth M., Hershey, Gurjit Khurana, Pauciulo, Michael W., Nichols, William C., Le Cras, Timothy D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302893/ https://www.ncbi.nlm.nih.gov/pubmed/22427841 http://dx.doi.org/10.1371/journal.pone.0032468

Ejemplares similares

Differential Effects of Rapamycin and Dexamethasone in Mouse Models of Established Allergic Asthma
por: Mushaben, Elizabeth M., et al.
Publicado: (2013)

A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia
por: Stange, Katja, et al.
Publicado: (2015)

Human liver single nuclear RNA sequencing implicates BMPR2, GDF15, arginine, and estrogen in portopulmonary hypertension
por: Jose, Arun, et al.
Publicado: (2023)

Modification of Hemodynamic and Immune Responses to Exposure with a Weak Antigen by the Expression of a Hypomorphic BMPR2 Gene
por: Park, Sung-Hyun, et al.
Publicado: (2013)

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling
por: Pickworth, Josephine, et al.
Publicado: (2017)

Oxidative Stress, Vascular Remodeling, and Vascular Inflammation in Hypertension
por: Renna, Nicolas Federico
Publicado: (2013)

BMPR2 spruces up the endothelium in pulmonary hypertension
por: Xiong, Jianhua
Publicado: (2015)

TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells
por: Burleson, J. D., et al.
Publicado: (2019)

The genetics of pulmonary arterial hypertension in the post-BMPR2 era
por: Fessel, Joshua P., et al.
Publicado: (2011)

A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype
por: Oriaku, Ifeoma, et al.
Publicado: (2020)

Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in BMPR2 Associated Pulmonary Arterial Hypertension
por: D’Amico, Reid W., et al.
Publicado: (2018)

Inflammation induces endothelial‐to‐mesenchymal transition and promotes vascular calcification through downregulation of BMPR2
por: Sánchez‐Duffhues, Gonzalo, et al.
Publicado: (2019)

Inflammation, immunity, and vascular remodeling in pulmonary hypertension; Evidence for complement involvement?
por: Frid, Maria G., et al.
Publicado: (2020)

Molecular and functional characterization of the BMPR2 gene in Pulmonary Arterial Hypertension
por: Pousada, Guillermo, et al.
Publicado: (2017)

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
por: Novoyatleva, Tatyana, et al.
Publicado: (2021)

Pulmonary Vascular Remodeling in Pulmonary Hypertension
por: Jia, Zhuangzhuang, et al.
Publicado: (2023)

Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension
por: Johnson, Jennifer A, et al.
Publicado: (2009)

A Novel BMPR2 Mutation Associated with Pulmonary Arterial Hypertension in an Octogenarian
por: Johri, Shilpa, et al.
Publicado: (2010)

Three novel BMPR2 mutations associated with advanced pulmonary arterial hypertension
por: Hara, Hironori, et al.
Publicado: (2017)

15 years journey of idiopathic pulmonary arterial hypertension with BMPR2 mutation
por: Ahn, Kyung Jin, et al.
Publicado: (2019)

Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension
por: West, James, et al.
Publicado: (2020)

Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation
por: Montani, David, et al.
Publicado: (2021)

Consequences of BMPR2 Deficiency in the Pulmonary Vasculature and Beyond: Contributions to Pulmonary Arterial Hypertension
por: Andruska, Adam, et al.
Publicado: (2018)

Diesel Exhaust Particles Induce Cysteine Oxidation and S-Glutathionylation in House Dust Mite Induced Murine Asthma
por: Lee, Gerald B., et al.
Publicado: (2013)

Inflammation and Vascular Remodeling
por: Aihara, Ken-ichi, et al.
Publicado: (2012)

The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension
por: Karoor, Vijaya, et al.
Publicado: (2021)

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects
por: Rigoni, Rosita, et al.
Publicado: (2016)

Hemodynamic and clinical onset in patients with hereditary pulmonary arterial hypertension and BMPR2 mutations
por: Pfarr, Nicole, et al.
Publicado: (2011)

Mutation in BMPR2 Promoter: A ‘Second Hit’ for Manifestation of Pulmonary Arterial Hypertension?
por: Viales, Rebecca Rodríguez, et al.
Publicado: (2015)

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
por: Long, Lu, et al.
Publicado: (2015)

BMPR2 Promoter Variants Effect Gene Expression in Pulmonary Arterial Hypertension Patients
por: Song, Jie, et al.
Publicado: (2020)

Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension
por: Chaikuad, Apirat, et al.
Publicado: (2019)

Author Correction: Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
por: Novoyatleva, Tatyana, et al.
Publicado: (2022)

Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension
por: Zhang, Vida, et al.
Publicado: (2022)

Genes in pediatric pulmonary arterial hypertension and the most promising BMPR2 gene therapy
por: Dai, Lingling, et al.
Publicado: (2022)

Is iron deficiency caused by BMPR2 mutations or dysfunction in pulmonary arterial hypertension patients?
por: Theobald, Vivienne, et al.
Publicado: (2023)

Therapeutic Interference With Vascular Calcification—Lessons From Klotho-Hypomorphic Mice and Beyond
por: Lang, Florian, et al.
Publicado: (2018)

Rapid generation of hypomorphic mutations
por: Arthur, Laura L., et al.
Publicado: (2017)

Pathophysiology of Vascular Remodeling in Hypertension
por: Renna, Nicolás F., et al.
Publicado: (2013)

Vascular Remodeling in Experimental Hypertension
por: Risler, Norma R., et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_o3olnklpr1u7l8n9jnoq07t35p