Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance

BACKGROUND: Cachexia is a multiorganic syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting and inflammation. METHODS: The aim of this investigation was to examine the effect of the soluble receptor antagonist of myostatin (sActRIIB) in cachectic tumo...

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Detalles Bibliográficos
Autores principales: Busquets, Sílvia, Toledo, Míriam, Orpí, Marcel, Massa, David, Porta, Maria, Capdevila, Eva, Padilla, Núria, Frailis, Valentina, López-Soriano, Francisco J., Han, H. Q., Argilés, Josep M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302990/
https://www.ncbi.nlm.nih.gov/pubmed/22450815
http://dx.doi.org/10.1007/s13539-011-0049-z
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author Busquets, Sílvia
Toledo, Míriam
Orpí, Marcel
Massa, David
Porta, Maria
Capdevila, Eva
Padilla, Núria
Frailis, Valentina
López-Soriano, Francisco J.
Han, H. Q.
Argilés, Josep M.
author_facet Busquets, Sílvia
Toledo, Míriam
Orpí, Marcel
Massa, David
Porta, Maria
Capdevila, Eva
Padilla, Núria
Frailis, Valentina
López-Soriano, Francisco J.
Han, H. Q.
Argilés, Josep M.
author_sort Busquets, Sílvia
collection PubMed
description BACKGROUND: Cachexia is a multiorganic syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting and inflammation. METHODS: The aim of this investigation was to examine the effect of the soluble receptor antagonist of myostatin (sActRIIB) in cachectic tumor-bearing animals analyzing changes in muscle proteolysis and in quality of life. RESULTS: Administration of sActRIIB resulted in an improvement in body and muscle weights. Administration of the soluble receptor antagonist of myostatin also resulted in an improvement in the muscle force. CONCLUSIONS: These results suggest that blocking myostatin pathway could be a promising therapeutic strategy for the treatment of cancer cachexia.
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spelling pubmed-33029902012-03-22 Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance Busquets, Sílvia Toledo, Míriam Orpí, Marcel Massa, David Porta, Maria Capdevila, Eva Padilla, Núria Frailis, Valentina López-Soriano, Francisco J. Han, H. Q. Argilés, Josep M. J Cachexia Sarcopenia Muscle Original Article BACKGROUND: Cachexia is a multiorganic syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting and inflammation. METHODS: The aim of this investigation was to examine the effect of the soluble receptor antagonist of myostatin (sActRIIB) in cachectic tumor-bearing animals analyzing changes in muscle proteolysis and in quality of life. RESULTS: Administration of sActRIIB resulted in an improvement in body and muscle weights. Administration of the soluble receptor antagonist of myostatin also resulted in an improvement in the muscle force. CONCLUSIONS: These results suggest that blocking myostatin pathway could be a promising therapeutic strategy for the treatment of cancer cachexia. Springer-Verlag 2011-11-08 2012-03 /pmc/articles/PMC3302990/ /pubmed/22450815 http://dx.doi.org/10.1007/s13539-011-0049-z Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Busquets, Sílvia
Toledo, Míriam
Orpí, Marcel
Massa, David
Porta, Maria
Capdevila, Eva
Padilla, Núria
Frailis, Valentina
López-Soriano, Francisco J.
Han, H. Q.
Argilés, Josep M.
Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance
title Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance
title_full Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance
title_fullStr Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance
title_full_unstemmed Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance
title_short Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance
title_sort myostatin blockage using actriib antagonism in mice bearing the lewis lung carcinoma results in the improvement of muscle wasting and physical performance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302990/
https://www.ncbi.nlm.nih.gov/pubmed/22450815
http://dx.doi.org/10.1007/s13539-011-0049-z
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