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Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate
We present direct evidence of an activator-inhibitor system in the generation of the regularly spaced transverse ridges of the palate. We show that new ridges, or rugae, marked by stripes of Sonic hedgehog (Shh) expression, appear at two growth zones where the space between previously laid-down ruga...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303118/ https://www.ncbi.nlm.nih.gov/pubmed/22344222 http://dx.doi.org/10.1038/ng.1090 |
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author | Economou, Andrew D. Ohazama, Atsushi Porntaveetus, Thantrira Sharpe, Paul T. Kondo, Shigeru Basson, M. Albert Gritli-Linde, Amel Cobourne, Martyn T. Green, Jeremy B.A. |
author_facet | Economou, Andrew D. Ohazama, Atsushi Porntaveetus, Thantrira Sharpe, Paul T. Kondo, Shigeru Basson, M. Albert Gritli-Linde, Amel Cobourne, Martyn T. Green, Jeremy B.A. |
author_sort | Economou, Andrew D. |
collection | PubMed |
description | We present direct evidence of an activator-inhibitor system in the generation of the regularly spaced transverse ridges of the palate. We show that new ridges, or rugae, marked by stripes of Sonic hedgehog (Shh) expression, appear at two growth zones where the space between previously laid-down rugae increases. However, inter-rugal growth is not absolutely required: new stripes still appear when growth is inhibited. Furthermore, when a ruga is excised new Shh expression appears, not at the cut edge but as bifurcating stripes branching from the neighbouring Shh stripe, diagnostic of a Turing-type reaction-diffusion mechanism. Genetic and inhibitor experiments identify Fibroblast Growth Factor (FGF) and Shh as an activator-inhibitor pair in this system. These findings demonstrate a reaction-diffusion mechanism likely to be widely relevant in vertebrate development. |
format | Online Article Text |
id | pubmed-3303118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-33031182012-09-01 Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate Economou, Andrew D. Ohazama, Atsushi Porntaveetus, Thantrira Sharpe, Paul T. Kondo, Shigeru Basson, M. Albert Gritli-Linde, Amel Cobourne, Martyn T. Green, Jeremy B.A. Nat Genet Article We present direct evidence of an activator-inhibitor system in the generation of the regularly spaced transverse ridges of the palate. We show that new ridges, or rugae, marked by stripes of Sonic hedgehog (Shh) expression, appear at two growth zones where the space between previously laid-down rugae increases. However, inter-rugal growth is not absolutely required: new stripes still appear when growth is inhibited. Furthermore, when a ruga is excised new Shh expression appears, not at the cut edge but as bifurcating stripes branching from the neighbouring Shh stripe, diagnostic of a Turing-type reaction-diffusion mechanism. Genetic and inhibitor experiments identify Fibroblast Growth Factor (FGF) and Shh as an activator-inhibitor pair in this system. These findings demonstrate a reaction-diffusion mechanism likely to be widely relevant in vertebrate development. 2012-02-19 /pmc/articles/PMC3303118/ /pubmed/22344222 http://dx.doi.org/10.1038/ng.1090 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Economou, Andrew D. Ohazama, Atsushi Porntaveetus, Thantrira Sharpe, Paul T. Kondo, Shigeru Basson, M. Albert Gritli-Linde, Amel Cobourne, Martyn T. Green, Jeremy B.A. Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate |
title | Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate |
title_full | Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate |
title_fullStr | Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate |
title_full_unstemmed | Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate |
title_short | Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate |
title_sort | periodic stripe formation by a turing-mechanism operating at growth zones in the mammalian palate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303118/ https://www.ncbi.nlm.nih.gov/pubmed/22344222 http://dx.doi.org/10.1038/ng.1090 |
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