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Strong physical constraints on sequence-specific target location by proteins on DNA molecules

Sequence-specific binding to DNA in the presence of competing non-sequence-specific ligands is a problem faced by proteins in all organisms. It is akin to the problem of parking a truck at a loading bay by the side of a road in the presence of cars parked at random along the road. Cars even partiall...

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Detalles Bibliográficos
Autores principales: Flyvbjerg, Henrik, Keatch, Steven A., Dryden, David T.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303175/
https://www.ncbi.nlm.nih.gov/pubmed/16698961
http://dx.doi.org/10.1093/nar/gkl271