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Prioritization of pathogenic mutations in the protein kinase superfamily

BACKGROUND: Most of the many mutations described in human protein kinases are tolerated without significant disruption of the corresponding structures or molecular functions, while some of them have been associated to a variety of human diseases, including cancer. In the last decade, a plethora of c...

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Detalles Bibliográficos
Autores principales: Izarzugaza, Jose MG, del Pozo, Angela, Vazquez, Miguel, Valencia, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303724/
https://www.ncbi.nlm.nih.gov/pubmed/22759651
http://dx.doi.org/10.1186/1471-2164-13-S4-S3