On the effect of protein conformation diversity in discriminating among neutral and disease related single amino acid substitutions

BACKGROUND: Non-synonymous coding SNPs (nsSNPs) that are associated to disease can also be related with alterations in protein stability. Computational methods are available to predict the effect of single amino acid substitutions (SASs) on protein stability based on a single folded structure. Howev...

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Detalles Bibliográficos
Autores principales: Juritz, Ezequiel, Fornasari, Maria Silvina, Martelli, Pier Luigi, Fariselli, Piero, Casadio, Rita, Parisi, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303731/
https://www.ncbi.nlm.nih.gov/pubmed/22759653
http://dx.doi.org/10.1186/1471-2164-13-S4-S5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303731/
https://www.ncbi.nlm.nih.gov/pubmed/22759653
http://dx.doi.org/10.1186/1471-2164-13-S4-S5

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