Effective Silencing of Sry Gene with RNA Interference in Developing Mouse Embryos Resulted in Feminization of XY Gonad

Delivering siRNA or shRNA into the developing embryos is still a main challenge to use of RNAi in mammalian systems. Here we analyze several factors influencing RNAi-mediated silencing of Sry gene, which is a tightly controlled spatiotemporal expressed gene and only shortly expressed in developing m...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Ning, Yu, Ai-Bing, Zhu, Hua-Bin, Lin, Xiu-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303865/
https://www.ncbi.nlm.nih.gov/pubmed/22500086
http://dx.doi.org/10.1155/2012/343891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303865/
https://www.ncbi.nlm.nih.gov/pubmed/22500086
http://dx.doi.org/10.1155/2012/343891

Ejemplares similares