A proximal pair of positive charges provides the dominant ligand-binding contribution to complement-like domains from the LRP (low-density lipoprotein receptor-related protein)

The LRP (low-density lipoprotein receptor-related protein) can bind a wide range of structurally diverse ligands to regions composed of clusters of ~40 residue Ca(2+)-dependent, disulfide-rich, CRs (complement-like repeats). Whereas lysine residues from the ligands have been implicated in binding, t...

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Detalles Bibliográficos
Autores principales: Gettins, Peter G. W., Dolmer, Klavs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304490/
https://www.ncbi.nlm.nih.gov/pubmed/22181833
http://dx.doi.org/10.1042/BJ20111867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304490/
https://www.ncbi.nlm.nih.gov/pubmed/22181833
http://dx.doi.org/10.1042/BJ20111867

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