Amyloid-Like Fibril Formation by PolyQ Proteins: A Critical Balance between the PolyQ Length and the Constraints Imposed by the Host Protein

Nine neurodegenerative disorders, called polyglutamine (polyQ) diseases, are characterized by the formation of intranuclear amyloid-like aggregates by nine proteins containing a polyQ tract above a threshold length. These insoluble aggregates and/or some of their soluble precursors are thought to pl...

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Detalles Bibliográficos
Autores principales: Scarafone, Natacha, Pain, Coralie, Fratamico, Anthony, Gaspard, Gilles, Yilmaz, Nursel, Filée, Patrice, Galleni, Moreno, Matagne, André, Dumoulin, Mireille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305072/
https://www.ncbi.nlm.nih.gov/pubmed/22438863
http://dx.doi.org/10.1371/journal.pone.0031253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305072/
https://www.ncbi.nlm.nih.gov/pubmed/22438863
http://dx.doi.org/10.1371/journal.pone.0031253

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