Highly Sensitive and Specific Detection of Rare Variants in Mixed Viral Populations from Massively Parallel Sequence Data

Viruses diversify over time within hosts, often undercutting the effectiveness of host defenses and therapeutic interventions. To design successful vaccines and therapeutics, it is critical to better understand viral diversification, including comprehensively characterizing the genetic variants in v...

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Detalles Bibliográficos
Autores principales: Macalalad, Alexander R., Zody, Michael C., Charlebois, Patrick, Lennon, Niall J., Newman, Ruchi M., Malboeuf, Christine M., Ryan, Elizabeth M., Boutwell, Christian L., Power, Karen A., Brackney, Doug E., Pesko, Kendra N., Levin, Joshua Z., Ebel, Gregory D., Allen, Todd M., Birren, Bruce W., Henn, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305335/
https://www.ncbi.nlm.nih.gov/pubmed/22438797
http://dx.doi.org/10.1371/journal.pcbi.1002417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305335/
https://www.ncbi.nlm.nih.gov/pubmed/22438797
http://dx.doi.org/10.1371/journal.pcbi.1002417

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