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Network Evolution: Rewiring and Signatures of Conservation in Signaling

The analysis of network evolution has been hampered by limited availability of protein interaction data for different organisms. In this study, we investigate evolutionary mechanisms in Src Homology 3 (SH3) domain and kinase interaction networks using high-resolution specificity profiles. We constru...

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Detalles Bibliográficos
Autores principales: Sun, Mark G. F., Sikora, Martin, Costanzo, Michael, Boone, Charles, Kim, Philip M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305342/
https://www.ncbi.nlm.nih.gov/pubmed/22438796
http://dx.doi.org/10.1371/journal.pcbi.1002411