Mitochondrial Oxidative Stress Alters a Pathway in Caenorhabditis elegans Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates

Mammalian bile acids (BAs) are oxidized metabolites of cholesterol whose amphiphilic properties serve in lipid and cholesterol uptake. BAs also act as hormone-like substances that regulate metabolism. The Caenorhabditis elegans clk-1 mutants sustain elevated mitochondrial oxidative stress and displa...

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Detalles Bibliográficos
Autores principales: Liu, Ju-Ling, Desjardins, David, Branicky, Robyn, Agellon, Luis B., Hekimi, Siegfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305355/
https://www.ncbi.nlm.nih.gov/pubmed/22438816
http://dx.doi.org/10.1371/journal.pgen.1002553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305355/
https://www.ncbi.nlm.nih.gov/pubmed/22438816
http://dx.doi.org/10.1371/journal.pgen.1002553

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