Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells

BACKGROUND: Nonstructural glycoprotein 4 (NSP4) encoded by rotavirus is the only viral protein currently believed to function as an enterotoxin. NSP4 is synthesized as an intracellular transmembrane glycoprotein and as such is essential for virus assembly. Infection of polarized Caco-2 cells with ro...

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Detalles Bibliográficos
Autores principales: Didsbury, Alicia, Wang, Carol, Verdon, Daniel, Sewell, Mary A, McIntosh, Julie D, Taylor, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305486/
https://www.ncbi.nlm.nih.gov/pubmed/22185400
http://dx.doi.org/10.1186/1743-422X-8-551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305486/
https://www.ncbi.nlm.nih.gov/pubmed/22185400
http://dx.doi.org/10.1186/1743-422X-8-551

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