Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor

The purpose of this study was to detect saccharide-protein interaction capitalizing on the gel-modified field effect transistor [FET]. A lectin-sensitive polymer gel that undergoes volume changes in response to the formation of molecular complex between 'pendant' carbohydrate and a 't...

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Detalles Bibliográficos
Autores principales: Maeda, Yasuhiro, Matsumoto, Akira, Miura, Yoshiko, Miyahara, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305491/
https://www.ncbi.nlm.nih.gov/pubmed/22313907
http://dx.doi.org/10.1186/1556-276X-7-108
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author Maeda, Yasuhiro
Matsumoto, Akira
Miura, Yoshiko
Miyahara, Yuji
author_facet Maeda, Yasuhiro
Matsumoto, Akira
Miura, Yoshiko
Miyahara, Yuji
author_sort Maeda, Yasuhiro
collection PubMed
description The purpose of this study was to detect saccharide-protein interaction capitalizing on the gel-modified field effect transistor [FET]. A lectin-sensitive polymer gel that undergoes volume changes in response to the formation of molecular complex between 'pendant' carbohydrate and a 'target' lectin concanavalin A [Con A] was synthesized. It was revealed that direction and magnitude of the gel response (swelling or deswelling) could be readily designed depending on composition and network density of the gel. The Con A-sensitive polymer gel has shown the ability to transduce the detection of saccharide-protein interactions into electrical signals for FET. PACS: 87.85.jf, bio-based materials
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spelling pubmed-33054912012-03-16 Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor Maeda, Yasuhiro Matsumoto, Akira Miura, Yoshiko Miyahara, Yuji Nanoscale Res Lett Nano Express The purpose of this study was to detect saccharide-protein interaction capitalizing on the gel-modified field effect transistor [FET]. A lectin-sensitive polymer gel that undergoes volume changes in response to the formation of molecular complex between 'pendant' carbohydrate and a 'target' lectin concanavalin A [Con A] was synthesized. It was revealed that direction and magnitude of the gel response (swelling or deswelling) could be readily designed depending on composition and network density of the gel. The Con A-sensitive polymer gel has shown the ability to transduce the detection of saccharide-protein interactions into electrical signals for FET. PACS: 87.85.jf, bio-based materials Springer 2012-02-07 /pmc/articles/PMC3305491/ /pubmed/22313907 http://dx.doi.org/10.1186/1556-276X-7-108 Text en Copyright ©2012 Maeda et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nano Express
Maeda, Yasuhiro
Matsumoto, Akira
Miura, Yoshiko
Miyahara, Yuji
Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor
title Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor
title_full Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor
title_fullStr Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor
title_full_unstemmed Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor
title_short Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor
title_sort preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305491/
https://www.ncbi.nlm.nih.gov/pubmed/22313907
http://dx.doi.org/10.1186/1556-276X-7-108
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