Regulation of p14(ARF )expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

BACKGROUND: Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the RB1 tumor suppressor gene, TP53 mutations have not been found. High expression of the p53-antagonist MDM2 in human retinoblastomas may compromise p53 tumor surveillance...

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Detalles Bibliográficos
Autores principales: To, Kwong-Him, Pajovic, Sanja, Gallie, Brenda L, Thériault, Brigitte L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305684/
https://www.ncbi.nlm.nih.gov/pubmed/22336108
http://dx.doi.org/10.1186/1471-2407-12-69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305684/
https://www.ncbi.nlm.nih.gov/pubmed/22336108
http://dx.doi.org/10.1186/1471-2407-12-69

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