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Regulation of p14(ARF )expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development
BACKGROUND: Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the RB1 tumor suppressor gene, TP53 mutations have not been found. High expression of the p53-antagonist MDM2 in human retinoblastomas may compromise p53 tumor surveillance...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305684/ https://www.ncbi.nlm.nih.gov/pubmed/22336108 http://dx.doi.org/10.1186/1471-2407-12-69 |