Inhibition of glycogen synthase kinase 3β prevents NSAID-induced acute kidney injury

Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by multiple adverse effects, including renal toxicity leading to acute kidney injury. In mice with DCLF-induced nephrotoxicity TDZD-8, a selective glycogen synthase kinase (GSK)3β inhibitor, improved acu...

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Detalles Bibliográficos
Autores principales: Bao, Hao, Ge, Yan, Zhuang, Shougang, Dworkin, Lance D, Liu, Zhihong, Gong, Rujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305839/
https://www.ncbi.nlm.nih.gov/pubmed/22258319
http://dx.doi.org/10.1038/ki.2011.443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305839/
https://www.ncbi.nlm.nih.gov/pubmed/22258319
http://dx.doi.org/10.1038/ki.2011.443

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