Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma

BACKGROUND: The mammalian target of rapamycin (mTOR) protein is important for cellular growth and homeostasis. The presence and prognostic significance of inappropriate mTOR activation have been reported for several cancers. Mammalian target of rapamycin inhibitors, such as everolimus (RAD001), are...

Descripción completa

Detalles Bibliográficos
Autores principales: Hirashima, K, Baba, Y, Watanabe, M, Karashima, R-I, Sato, N, Imamura, Y, Nagai, Y, Hayashi, N, Iyama, K-I, Baba, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305959/
https://www.ncbi.nlm.nih.gov/pubmed/22333597
http://dx.doi.org/10.1038/bjc.2012.36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305959/
https://www.ncbi.nlm.nih.gov/pubmed/22333597
http://dx.doi.org/10.1038/bjc.2012.36

Ejemplares similares