Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

The expression of the renoprotective antiaging gene Klotho is decreased in uremia. Recent studies suggest that Klotho may be a tumor suppressor, and its expression may be repressed by DNA hypermethylation in cancer cells. Here we investigated the effects and possible mechanisms by which Klotho expre...

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Detalles Bibliográficos
Autores principales: Sun, Chiao-Yin, Chang, Shih-Chung, Wu, Mai-Szu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306006/
https://www.ncbi.nlm.nih.gov/pubmed/22237753
http://dx.doi.org/10.1038/ki.2011.445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306006/
https://www.ncbi.nlm.nih.gov/pubmed/22237753
http://dx.doi.org/10.1038/ki.2011.445

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