Structures of Helicobacter pylori Shikimate Kinase Reveal a Selective Inhibitor-Induced-Fit Mechanism

Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids. This pathway is present in bacteria, fungi, and plants but absent in...

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Detalles Bibliográficos
Autores principales: Cheng, Wen-Chi, Chen, Yen-Fu, Wang, Hung-Jung, Hsu, Kai-Cheng, Lin, Shuang-Chih, Chen, Tzu-Jung, Yang, Jinn-Moon, Wang, Wen-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306394/
https://www.ncbi.nlm.nih.gov/pubmed/22438938
http://dx.doi.org/10.1371/journal.pone.0033481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306394/
https://www.ncbi.nlm.nih.gov/pubmed/22438938
http://dx.doi.org/10.1371/journal.pone.0033481

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