Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling

Alzheimer disease (AD) is a heterogeneous neurodegenerative disorder characterized by (1) progressive loss of synapses and neurons, (2) intracellular neurofibrillary tangles, composed of hyperphosphorylated Tau protein, and (3) amyloid plaques. Genetically, AD is linked to mutations in few proteins...

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Detalles Bibliográficos
Autores principales: Nizzari, Mario, Thellung, Stefano, Corsaro, Alessandro, Villa, Valentina, Pagano, Aldo, Porcile, Carola, Russo, Claudio, Florio, Tullio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306972/
https://www.ncbi.nlm.nih.gov/pubmed/22496686
http://dx.doi.org/10.1155/2012/187297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306972/
https://www.ncbi.nlm.nih.gov/pubmed/22496686
http://dx.doi.org/10.1155/2012/187297

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