A point mutation in the DNA-binding domain of HPV-2 E2 protein increases its DNA-binding capacity and reverses its transcriptional regulatory activity on the viral early promoter

BACKGROUND: The human papillomavirus (HPV) E2 protein is a multifunctional DNA-binding protein. The transcriptional activity of HPV E2 is mediated by binding to its specific binding sites in the upstream regulatory region of the HPV genomes. Previously we reported a HPV-2 variant from a verrucae vul...

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Detalles Bibliográficos
Autores principales: Gao, Chen, Pan, Ming-Ming, Lei, Yan-Jun, Tian, Li-Qing, Jiang, Hui-Ying, Li, Xiao-Li, Shi, Qi, Tian, Chan, Yuan, Yu-Kang, Fan, Gui-Xiang, Dong, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307029/
https://www.ncbi.nlm.nih.gov/pubmed/22333459
http://dx.doi.org/10.1186/1471-2199-13-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307029/
https://www.ncbi.nlm.nih.gov/pubmed/22333459
http://dx.doi.org/10.1186/1471-2199-13-5

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