Small-molecule inhibitor starting points learned from protein–protein interaction inhibitor structure

Motivation: Protein–protein interactions (PPIs) are a promising, but challenging target for pharmaceutical intervention. One approach for addressing these difficult targets is the rational design of small-molecule inhibitors that mimic the chemical and physical properties of small clusters of key re...

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Detalles Bibliográficos
Autores principales: Koes, David Ryan, Camacho, Carlos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307105/
https://www.ncbi.nlm.nih.gov/pubmed/22210869
http://dx.doi.org/10.1093/bioinformatics/btr717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307105/
https://www.ncbi.nlm.nih.gov/pubmed/22210869
http://dx.doi.org/10.1093/bioinformatics/btr717

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