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Small-molecule inhibitor starting points learned from protein–protein interaction inhibitor structure
Motivation: Protein–protein interactions (PPIs) are a promising, but challenging target for pharmaceutical intervention. One approach for addressing these difficult targets is the rational design of small-molecule inhibitors that mimic the chemical and physical properties of small clusters of key re...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307105/ https://www.ncbi.nlm.nih.gov/pubmed/22210869 http://dx.doi.org/10.1093/bioinformatics/btr717 |